A patient with APS must meet at least one of two clinical criteria (vascular thrombosis or complications of pregnancy) and at least one of two laboratory criteria including the persistent presence of lupus anticoagulant (LA), anticardiolipin antibodies (aCL) and/or anti-β2GPI antibodies of IgG or IgM isotype at medium to high titres in patient’s plasma. This evidence concerns the gene CD40LG and autoimmune polyendocrinopathy.