OGG1 and chronic obstructive pulmonary disease: Authors reported significant oxidation of nucleic acids localized to alveolar lung fibroblasts, increased levels of 8-oxoguanine-DNA glycosylase mRNA expression, and decreased concentrations of endonuclease III homologue 1, single-strand-selective monofunctional uracil-DNA glycosylase 1, and Y-box binding protein 1 mRNA in lung samples obtained from subjects with very severe COPD compared with COPD in stages 2-3 (study was published in 2010 and this is why authors used old GOLD classification of severity of the disease) or no-COPD [132].