In another study, the intake of DSW has reduced allergic skin responses and serum levels of total IgE, Japanese cedar pollen-specific IgE, interleukin-4 (IL-4), IL-6, IL-13, and IL-18 in the patients with allergic rhinitis, compared to the distilled water intake which fails to give those effects [32]. The gene discussed is IGHE; the disease is allergic rhinitis.