MAPT and Alzheimer disease: Alzheimer reported the results of an autopsy on a 55-year-old woman named Auguste Deter and noted the presence of two distinct pathological lesions in Deters brain, which now define Alzheimer's disease (AD): first, the neurofibrillary tangles (NFTs), which accumulate intraneuronal (later shown to be composed of paired helical filaments (PHFs) containing the microtubule-associated protein tau; Goedert et al., 1988, 1989); second, extracellular amyloid deposits in the form of diffuse or neuritic senile plaques (Price et al., 1997).