BACE1 and early-onset autosomal dominant Alzheimer disease: Notably, the human sequence of the Swedish familiar Alzheimer disease mutation (APPswe) is used in almost all AD animal models as it serves as a better substrate for BACE-1, thereby increasing production of total Aβ and specifically 1-X Aβ peptides (Citron et al., 1992; Cai et al., 1993).