Apart from epilepsy models MMP-9 was observed to cause cell death contributing, for example, to impairment of transmission between ECM and the cell through the lipoprotein receptor-related protein [107], separation of the cells from ECM leading to anoikis, the kind of apoptosis caused by the activation of proteolytic cascades [108], an increase of calpain activation [109], and initiation of caspase cascade and induction of cytotoxicity [77]. This evidence concerns the gene MMP9 and epilepsy.