Our result is also consistent with previous reports that GATA2 is one of the more commonly mutated genes in MDS/AL predisposition syndromes.8, 14 Four of the five GATA2 deleterious variants were novel, and four of them were located in the ZF2 domain, further emphasizing this domain as a mutational hot spot (Table 2 and Supplementary Figure 2). The gene discussed is GATA2; the disease is myelodysplastic syndrome.