Tumor-associated macrophage cells can secrete different matrix metalloproteinases (MMPs), which can degrade the ECM, leading to the release of additional matrix-sequestered growth factors and providing activated ECs with space to migrate to.17 Similarly, differentiated tumor-associated neutrophils, contribute to ECM remodeling by the secretion of MMP9, which leads to the release of matrix-bound growth factors such as VEGF.18 Functionally, MMPs have been linked to tumor angiogenesis and metastasis.19 This evidence concerns the gene MMP9 and neoplasm.