MYC and cancer: Both aerobic glycolysis and glutaminolysis are simultaneously activated in malignant cancer cells.34 Recently, it has been reported that a MYC transcriptional target mediates elevation of glutaminolysis, being essential for lactate transport and glycolytic flux in several cancer cell lines.35, 36 Lactate in the extracellular space promotes the acidic condition, which in turn leads to pseudo-hypoxia.