Restored citrate, induced by ACL inhibition, is linked to HIF1α activation and stabilization.39, 81 Several miRs that mediate metabolic re-programming can contribute to HIF-1α expression and stabilization.91 In chronic lymphocytic leukemia, stabilization of HIF-1α under normoxia is mediated by miR-92-1, which targets the VHL tumor suppressor,92 an E3 ubiquitin ligase involved in the degradation of HIF-1α in the presence of oxygen. The gene discussed is HIF1A; the disease is B-cell chronic lymphocytic leukemia.