The expression pattern of selected genes, namely kidney injury molecule-1 (KIM1), fibronectin 1 (FN1), insulin like growth factor binding protein 1 (IGFBP1), insulin like growth factor binding protein 3 (IGFBP3), kallikrein 1 (KLK1), glutathione S transferase mu 1 (GSTM1), glutamate cysteine ligase catalytic subunit (GCLC), glucose-6-phosphate dehydrogenase (G6PD), cytochrome P450 enzyme 2D6 (CYP2D6) and 2C19 (CYP2C19) were analyzed in both chronic kidney disease patients of known and unknown etiology residing in Girandurukotte, a CKDu endemic area belonging to the dry zone of Sri Lanka. The gene discussed is KLK1; the disease is chronic kidney disease.