This is illustrated e.g. by the SNVs in PTEN (p.Cys124Ser and p.Ala126Thr) and ARID1A (p.Arg1053fs) which were found in both, the endometrial and the ovarian endometrioid carcinoma, but were not conserved in the distant lung metastasis. This evidence concerns the gene PTEN and ovarian endometrioid carcinoma.