MET activation, which may be driven by stromal HGF expression, has been shown to mediate melanoma growth, dissemination, and resistance to BRAF inhibition in multiple preclinical models (Puri et al, 2007; Kabbarah et al, 2010; Vergani et al, 2011; Straussman et al, 2012). This evidence concerns the gene HGF and melanoma.