With better study in many other types of cancers including ovarian cancer [63], hepatocellular carcinoma [64], lung cancer [65] and breast cancer [66], HOTAIR was reported to have a role as a molecular scaffold binding PRC2 through the 5′ domain and LSD1/CoREST/REST complexes through the 3′ domain, so as to participate in tumor development by promoting histone H3K27 trimethylation and inhibiting gene expression [67, 68]. The gene discussed is HOTAIR; the disease is neoplasm.