EFEMP1 and cancer: Accordingly, the adjusted meta-analyses manifested that humoral fibulin-3 yielded a pooled sensitivity of 0.62 (95% CI: 0.45–0.77), specificity of 0.82 (95% CI: 0.73–0.89) and AUC of 0.81 in differentiating MPM patients from cancer-free participants (Figure 3A–3C).