Over the course of the experiment, there were no differences in ALS-induced weight loss between ALS mice homozygote for the K108N-SEMA3A mutation (Fig 1A; ALS x N/N, red curve) and ALS mice heterozygote for the K108N-SEMA3A mutation mice (Fig 1A; ALS x N/-, blue curve): these animals followed the same progressive decrease in weight loss as the ALS mice expressing the wild-type SEMA3A (Fig 1A; ALS, green curve). This evidence concerns the gene SEMA3A and amyotrophic lateral sclerosis.