In addition, inhibition of the UCK2 enzyme activity by FKB and APN exhibited a strong correlation to the MDM2-p52 signalling pathway, in which current investigations have demonstrated the ability of FKB and APN in the destruction of the MDM2-p53 complex, in turn, being the cause of the activation of p53, which is essential in triggering cell cycle arrest and apoptosis induction in the cancer cells. The gene discussed is MDM2; the disease is cancer.