Moreover, a significant higher expression of 18S and NHP2L1 was observed in AML samples in series 2, although with lower p-values than NCL and NOP56. Thus, comparison of analysis of both the series 1 and 2 identified NCL and NOP56 as the genes involved in ribosome biogenesis, which are the most significantly over-expressed in AML blasts. This evidence concerns the gene SNU13 and acute myeloid leukemia.