The 75th percentile was used to dichotomize gene expression in two groups, “low” and “high” NCL expression levels since (1) the highest levels of NCL expression in healthy donors correspond to about the NCL median levels in AML patients (Fig 2A), (2) NCL is over-expressed in AML patients compared to healthy donors (Table 2), and (3) the fold-changes of NCL displayed one of the largest dispersion (S6A Fig). This evidence concerns the gene NUCLEOLIN and acute myeloid leukemia.