Alikhani-Koopaei et al. [20] found that proximal kidney tubules with hypermethylation of the HSD11B2 promoter almost do not express 11βHSD2 and DNA methyltransferase inhibitors decrease methylation of the HSD11B2 promoter of the kidney to upregulate its expression in cell lines and in vivo, indicating DNA methylation affecting HSD11B2 gene expression correlates with hypertension. This evidence concerns the gene HSD11B2 and Hypertension.