HTR2A and psychiatric disorder: Regarding the biological function of rs6313, in 2002, Polesskaya, in subjects with no history of mental disorders, reported that the presence of the C allele in rs6313 reduced the expression of the HTR2A gene by 20% compared with the T allele and that this was correlated with the protein levels [22]; however, they clarify that these findings should not be generalized because such studies may vary according to the study population.