TLR4 and neoplasm: [25] Numerous pathways are involved in tumor growth are affected by EGCG including suppression of NF-κB, [26] inhibition of phosphoinositide-3-kinase (PI3K), [27] Akt and STAT3 signaling, [28] down-regulation of TLR4 signal transduction, activation of 67-kDa laminin receptor (67LR) [29] and synergistic effects with anticancer drugs and micronutrients.