Moreover, in vivo findings demonstrated that PrPc overexpression can induce spontaneous neurodegeneration,14, 15 and that local PrPc overexpression in muscles leads to primary myopathy, most likely via a p53 pathway.16 Earlier, we reported disturbed cellular homeostasis following PrPc overexpression in human neuroblastoma SH-SY5Y cells, but were unable to show that a sole overexpression of PrPc can alter p53 levels.17 The gene discussed is PRNP; the disease is neuroblastoma.