Human cytomegalovirus has been shown to promote apoptosis in NSPCs by enhancing ER stress and mitochondrial malfunction.14 A very recent report also portrays death of hNPCs infected by Zika virus at 72 h post infection by activation of caspase 3.12 As we observed JEV-induced cytopathic effect in both hNS1 and hNPCs (Figures 1a and 6a), we investigated the status of the apoptotic mediator proteins in these cells. The gene discussed is CASP3; the disease is infection.