CXCR4 and hepatocellular carcinoma: On the basis of their expression levels in the tumors, we found that the presence of any two indicators among HBx/MDM2/CXCR4/OV6 could predict malignant clinicopathological features and a poor prognosis for patients with HBV-related HCC (Figures 8b–d and Supplementary Tables S1–3).