First, qRT-PCR and IHC analysis were conducted in HCC specimens from 267 patients (Figure 8a), which revealed a close correlation between HBx and CXCR4, MDM2 and CXCR4, and CXCR4 and OV6 (P<0.0001) (Supplementary Figures S5A–C). The gene discussed is CXCR4; the disease is hepatocellular carcinoma.