TP53 and neoplasm: Mounting evidence has shown that MDM2 is frequently overexpressed in the majority of malignances and promotes tumor development by negatively regulating the p53 pathway.31, 32, 33 To substantiate our screening results, qRT-PCR and western blot assays were performed to verify the expression of MDM2 in sorted OV6+ cells expressing either HBx or the control vector.