These results suggest that a combination of any two parameters among HBx/MDM2/CXCR4/OV6 could serve as a powerful predictor for poor prognosis, further supporting the critical role of HBx/MDM2/CXCR4 signaling in OV6+ cancer cells in the progression of HCC. The gene discussed is CXCR4; the disease is hepatocellular carcinoma.