They allow the regulatory network to maintain bi-stable states.44 In a previous study, miR-489 and HER2-SHP2-MAPK signaling axis form a double-negative feedback loop that can regulate breast cancer cell proliferation and tumor progression.45 A double-negative feedback loop involving ZEB2 and miR-145 has a critical role in EMT and stemness maintenance during bone metastasis of prostate cancer cells.46 Here we reveal that lncRNA-H19, functioning as a ceRNA, links the network of miRNA let-7 and core transcription factor LIN28. This evidence concerns the gene ZEB2 and Familial prostate cancer.