However, inflammation also contributes and supports tumorigenesis and metastasis favouring homing of disseminated tumour cells in new tissues.9 Cytokines and growth factors mediate a cross-talk between epithelial cells and surrounding stromal cells that are crucial for cancer initiation, progression and metastases formation.10, 11, 12 Some factors, such as PDGF and VEGF, released in the tumour microenvironment, can promote tumour neoangiogenesis through the differentiation of endothelial progenitors into new vessels.13, 14. This evidence concerns the gene VEGFA and neoplasm.