Further survival analysis established that NPC patients with high ITGA3 expression had significantly poorer overall survival (OS; HR, 3.91; 95% CI, 1.90–8.06; P<0.001) as well as distant metastasis-free survival (DMFS; HR, 4.91; 95% CI, 1.90–12.69; P<0.001). This evidence concerns the gene ITGA3 and nasopharyngeal carcinoma.