For example, a neutralizing antibody to HGF exhibited potent antitumor effect in the treatment of glioblastoma multiforme.40 However, tumor growth became HGF-independent after repeated treatments.41 Conceivably, the promiscuous nature of H2O2 interactions with cellular signaling components, especially membrane-associated molecules such as EGFR and Met, renders the cells less dependent on ligand-activated pathways to promote transformation and growth. This evidence concerns the gene HGF and glioblastoma.