One group shows that autophagy may facilitate FMDV growth as FMDV yields are reduced in Atg5−/− MEF cells.33 However, other researchers have reported that FMDV utilizes autophagy to promote viral replication.33, 34, 35 Here, we reported that FMDV infection rapidly induced autophagy at the early infection stage, and subsequently suppressed autophagy via degradation of ATG5-ATG12 when viral protease 3Cpro was synthesized. Here, ATG5 is linked to infection.