It seems promising that combination of the dual phosphoinositide 3-kinase-MTOR inhibitor BEZ235 and the PLK1 inhibitor BI2536 in xenograft models of colorectal cancer shows that either inhibitor alone fails to enhance apoptosis, but combinatorial treatment inhibits MTORC1 readouts and leads to massive tumor cell death.73 The gene discussed is PLK1; the disease is colorectal cancer.