This is strengthened by the identification of a role for mutations in the sarcoplasmic reticulum (SR) associated proteins PLN and RYR2, and the fact that in the other 40% of patients diagnosed with ARVC, no causative mutations, or mutations not yet linked to ARVC, have been detected thus far [1]. This evidence concerns the gene RYR2 and arrhythmogenic right ventricular cardiomyopathy.