Mutations in genes encoding the desmosomal proteins PKP2, plakoglobin (gene name JUP), desmoplakin (DSP), desmocollin-2 (DSC2) and desmoglein-2 (DSG2), are highly related to development of ARVC [1]. The gene discussed is DSG2; the disease is arrhythmogenic right ventricular cardiomyopathy.