We checked the gene copy number, mRNA transcript and protein expression levels of MYC in our panel of NSCLC and HBEC lines and did not find a correlation between loss of SMARCA4, amplification of MYC and differential sensitivity to VX-680 (Supplementary Data 4–6, Supplementary Figs 9a–e and 7b). This evidence concerns the gene SMARCA4 and non-small cell lung carcinoma.