INS and Insulin resistance: Intriguingly, fastingblood glucose and insulin as well as Homeostasis model assessment of insulin resistance (HOMA-IR) levels were lower in Hmox1fl/flPdgfraCre as compared to Hmox1fl/fl control mice (Fig. 6A–C), indicating improved metabolic health in the HFD-treated Hmox1fl/flPdgfraCre mice.