In this context, given the results obtained in two different Drosophila models of Parkinson disease (PD-LRRK2-LOF and PD-PINK1B9-LOF) with the application of two methanolic extracts of parts of the medicinal plants, Withania somnifera and Mucuna pruriens widely used in the Ayurvedic medicine17, 18, 19, 22, 23, 24 for their potential effects on treating many central nervous system disorders, we deemed to investigate their effects on ALS symptoms. This evidence concerns the gene LRRK2 and amyotrophic lateral sclerosis.