Thus, based on the observations (1) that the PD-LRRK2 and ALS-SOD1 diseases share common oxidative stress- and neuroinflammation-based mechanisms and (2) that both Withania somnifera and Mucuna pruriens are endowed with potent anti-oxidative and anti-inflammatory properties, the results of the present study are expected to provide new data on the pathophysiology of ALS models and to suggest possible new vistas in the inflammatory, oxidative stress, genetic roles correlated to this neurodegeneration. Here, LRRK2 is linked to Parkinson disease.