Not surprisingly, the most abundant components of the HNSCC CAF matrisome correspond to proteins that are either upregulated by TGF-β (for example, FN, TGFBI and TNC) or proteins involved in TGF-β storage and activation by cellular receptors (including FN, fibrillins and latent TGF-β-binding proteins). The gene discussed is TNC; the disease is head and neck squamous cell carcinoma.