CNR1 and Huntington disease: To evaluate the relevance of the A2AR-CB1R heteromer in a pathological setting we selected HD as a model because (i) it is the paradigmatic disease primarily caused by a selective loss of MSNs in the dorsal striatum (Walker, 2007), and (ii) changes in the expression and function of A2AR and CB1R have been shown to occur in the dorsal striatum of patients and animal models of the disease (Glass et al, 2000; Fernandez-Ruiz et al, 2011; Lee and Chern, 2014).