NR3C1 and breast cancer: To this aim, we retrieved two signatures of GR activation from two independent published datasets obtained from GC-stimulated genes in MDA-MB-231 and A549 cells25, 40 and found that GR transcriptional activity is associated with molecular signatures of breast stem cells in a metadata set of 3,661 primary human breast cancers (Supplementary Fig. 6e)41, 42.