Although there was increased expression of GnRHR and LHCGR in wild-type APA patients and less in KCNJ5 mutation adenoma42, we further showed patients harboring CTNNB1 mutations over-expressed GnRHR and LHCGR compared adenomas with KCNJ5 mutation in both genders. The gene discussed is CTNNB1; the disease is adenoma.