These results are in contrast to survival times of WT or Col5a3−/− mice injected with WT/PyMT cells, in which mouse survival was only up to ∼30 or ∼45 days post injection, respectively (Fig. 2a), and in which tumours were first palpable only ∼14 days post injection (Fig. 2b). This evidence concerns the gene COL5A3 and neoplasm.