Specifically, number of liver metastases >1 (HR 1.420, 95% CI: 1.105–1.824, P = 0.006), preoperative CEA >200 ng/mL (HR 1.723, 95% CI: 1.121–2.646, P = 0.013), positive (R1) microscopic margin (HR 1.309, 95% CI: 1.027–1.669, P = 0.030), concomitant resection of extrahepatic disease (HR 2.489, 95% CI: 1.309–4.731, P = 0.005), and absence of repeat hepatectomy (HR 0.672, 95% CI: 0.483–0.935, P = 0.018) were independently associated with shortened cancer‐specific survival. This evidence concerns the gene CEACAM5 and cancer.