On the contrary, enhanced Ink4/Arf and p53 activity preserves mice from spontaneous or chemically induced cancers (Garcia‐Cao et al., 2002; Tyner et al., 2002; Maier et al., 2004; Matheu et al., 2004, 2007, 2009; Mendrysa et al., 2006). Here, CDKN2A is linked to cancer.