The cytokines in the tumor microenvironment can either promote antitumor immunity (IL-12, IFN-γ), enhance tumor development and progression (IL-6, IL-17, IL-23) [30], or influence the cancer cell growth and survival (TRAIL, FasL, TNF-α, TGF-β, IL-6). The gene discussed is TGFB1; the disease is neoplasm.