Our current data revealed that IL-17 was produced primarily by the CD4+ Tcm and CD4+ Tem cells, not by other CD4+ and CD8+ T cell subsets, which is consistent with the reports that 99% of the tumor-infiltrating IL-17 T cells were IL-17 CD4+ (Th17) cells [40, 41]. The gene discussed is CD4; the disease is neoplasm.