The levels of IFN-γ, TNF-α, and IL-17 cytokine-expressing CD4+ and CD8+ Tem cells were decreased in the blood from the NSCLC patients compared to the healthy donors (CD4 group, p ≤ 0.04; CD8 group, p ≤ 0.003) (Fig. 5b, Supplementary 4). This evidence concerns the gene CD8A and non-small cell lung carcinoma.