Only a small proportion (about 4%) of the naïve CD4+ T cells from the blood of healthy donor produced IFN-γ (Fig. 2a), and no significant difference was observed between healthy donors and the NSCLC patients in IFN-γ production by the CD4+ Tn cells from the blood (Fig. 2b). This evidence concerns the gene CD4 and non-small cell lung carcinoma.