In acute myeloid leukemia, NK cells became suppressed by tumor-derived microvesicles via TGF-β1 on the exosome surface (Szczepanski et al. 2011), and breast cancer-derived exosomes suppressed T-cell proliferation through this cytokine (Rong et al. 2016). The gene discussed is TGFB1; the disease is breast carcinoma.