APC and cerebral malaria: More significantly, the CIDRα1 domains from P. reichenowi share the capacity of CIDRα1.4 domains from P. falciparum to disrupt APC-EPCR binding in a manner that exacerbates the permeability of human brain endothelial cell monolayers in the presence of thrombin (30, 38, –, 40), a feature that may contribute to brain swelling and cerebral malaria pathophysiology (51, 56, 57).