HMGB1 and type 2 diabetes mellitus: Moreover, Dasu et al. [86] showed that circulating levels of HMGB1 were higher in type 2 diabetic patients than control, and the same phenomenon was observed by Škrha et al. [87] Hagiwara et al. [88] demonstrated that hyperglycemia, induced by infusion of glucose in a rat model, was associated with elevated serum HMGB1 levels.