POMC and Truncal obesity: These transgenic mice display Cushing-like features [1, 3, 4], namely elevated plasma levels of the adrenocorticotropic hormone (ACTH) and corticosterone, truncal obesity, muscle wasting, thinner skin, hair loss, immunosuppressive phenotype and insulin resistance linked with the chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis.