The decrease of WAT index, adipocyte diameter (Figures 1(b) and 1(c)), and plasma lipids (Figures 1(d)–1(f)) associated with the normal faecal lipid excretion (Figures 1(g)–1(j)) suggested an increased uptake of fatty acids by the liver as primary cause for the NAFLD observed in ACE2−/y mice. This evidence concerns the gene ACE2 and metabolic dysfunction-associated steatotic liver disease.