Wannamethee et al. [6] have reported that the greater adverse influence of diabetes per se on abdominal adiposity and insulin resistance, and down-stream blood pressure, lipids (low HDL-cholesterol), endothelial dysfunction (t-PA), and systemic inflammation (WBC) in women compared with men may contribute to their greater relative risk of coronary heart disease. Here, PLAT is linked to coronary artery disorder.