CD8A and neoplasm: In contrast to Wang et al. where a single set of best-fit parameters were used, here in silico model-based inference was used to determine whether the postulated topology of this multi-scale model was consistent with the observed response of CD8+ T cell to adenovirus vaccination and concomitant changes in the tumor microenvironment under all three experimental conditions (untreated, rHuAd5-hgp100, and rHuAd5-hDCT).