As summarized in Figure 6C, increasing IFNG production (kc1) slightly reduced tumor size (median for kc1: 86 mm2 vs. unmodified ACT of gp100 T cells: 92 mm2, p-value < 0.001) while the other two parameters had essentially no impact on tumor size (median for kd5a: 92 mm2 and kp3a: 91 mm2, p-values vs. unmodified both > 0.05). Here, PMEL is linked to neoplasm.