CD8A and neoplasm: Even if the number of TILs is increased, either through reducing the negative feedback on clonal expansion of CD8+ T cells in the lymph node (e.g., by decreasing ka) or adoptively transferring 100 times more DCT CD8+ T cells (see Figure 6), a further reduction in tumor growth is limited as the conversion of MHC class I negative to MHC class I positive cells (e.g., c3) becomes the rate limiting step for controlling tumor growth (see Figure 6C).