In vivo, PAR2 activation drives the development of hypertension (Emilsson et al., 1997; Cicala et al., 1999) and PAR2 expression is enhanced in aortas of diabetic mice and in human coronary atherosclerotic lesions (McGuire, 2004; Napoli et al., 2004). Here, F2RL1 is linked to hypertensive disorder.