TAC1 and enteritis: The link between substance P and damaging inflammation in the gut is further supported by the demonstration that NK-1R blockade abrogates intestinal inflammation associated with Clostridium difficile toxin A and Trichinella spiralis-induced enteritis (Swain et al., 1992; Agro and Stanisz, 1993; Kataeva et al., 1994; Castagliuolo et al., 1998).