In line with this, prolonging the attenuation of protein synthesis by genetic or pharmacological inhibition of GADD34 alleviates the S63del-CMT1B disease more efficiently than CHOP ablation, with improved hypomyelination, demyelination, motor performance and neurophysiological parameters (D'Antonio et al., 2013; Das et al., 2015). This evidence concerns the gene PPP1R15A and Charcot-Marie-Tooth disease type 1B.