PMP22 and Charcot-Marie-Tooth disease type 1A: Aggresomes have also been observed upon PMP22 mutations other than L16P and G150D and in a model of CMT1A with overexpression of wild-type PMP22 due to 7 extra-copies of the gene (Shames et al., 2003; Liu et al., 2004; Fortun et al., 2006).