Prediction of lung cancer risk with receiver operating characteristic (ROC) statistics for AHRR (cg05575921) methylation extent and the PLCOM2012 risk estimate produced similar area under curve (AUC) estimates in all 7120 ever smokers (p=0.11 for difference), but an AUC of 61% for AHRR (cg05575921) methylation extent versus 51% for the PLCOM2012 risk estimate in 2576 high-risk smokers (p=0.0001 for difference) (see online supplementary figure 7). The gene discussed is AHRR; the disease is lung cancer.