This suggests that AHRR cg05575921 methylation extent is less dynamic in adults than in new-borns, where more rapid attenuation of hypomethylation is seen once the antenatal exposure is removed.32 A small number of never smokers have low AHRR (cg05575921) methylation extent, presumably due to environmental exposures and may have increased risk of lung cancer. Here, AHRR is linked to lung cancer.