AHRR and lung carcinoma: This suggests that AHRR cg05575921 methylation extent is less dynamic in adults than in new-borns, where more rapid attenuation of hypomethylation is seen once the antenatal exposure is removed.32 A small number of never smokers have low AHRR (cg05575921) methylation extent, presumably due to environmental exposures and may have increased risk of lung cancer.